CELLular metabolism Over a life-course in socioeconomically disadvantaged populations

CELLO network wishes to address the biological cause for healthy ageing inequality.

Life expectancy is increasing but the period spent in good health is not keeping pace. Furthermore, the inequalities in healthy life expectancy are greater when the level of socioeconomic deprivation is taken into account. People living in the most deprived areas can expect to live their last 18 years in ill health. A key biological factor underpinning the inequality in healthy ageing seen in socioeconomic disadvantaged populations are changes in cellular metabolism. Indeed, many chronic age-related conditions are associated with metabolic dysregulation. Cellular metabolic dysfunction of the ageing cell is dictated by both intrinsic (genetic and pathway-driven) and extrinsic (environmental and epigenetic) mechanisms from an early age. As intrinsic and extrinsic factors never work in isolation, machine learning and artificial intelligence will be used to integrate both factors. Hence the purpose of this interdisciplinary network is to elucidate these mechanisms and the interaction between such factors. Only by understanding the changes in cellular metabolism throughout the life course can we identify ways of addressing this inequality.