In preprint: Understanding exogenous factors and biological mechanisms for cognitive frailty: a multidisciplinary scoping review

January 30, 2024

The scoping review on exogenous factors and biological mechanisms for cognitive frailty is currently in preprint! The multidisciplinary scoping review including 206 papers was a huge amount of work for the  CFIN Team led by Carol Holland (network PI), so we are really excited to share our findings and gap analysis with the world.

Understanding exogenous factors and biological mechanisms for cognitive frailty: a multidisciplinary scoping review

Carol HollandNikolett DraveczLauren OwensAlexandre BenedettoIrundika DiasAlan GowSusan Broughton

Cognitive frailty (CF) is the conjunction of cognitive impairment without dementia and physical frailty. While predictors of each element are well-researched, mechanisms of their co-occurrence have not been integrated, particularly in terms of relationships between social, psychological, and biological factors. This interdisciplinary scoping review set out to categorise a heterogenous multidisciplinary literature to identify potential pathways and mechanisms of CF, and research gaps. Studies were included if they used the definition of CF OR focused on conjunction of cognitive impairment and frailty, AND excluded studies on specific disease populations, interventions, epidemiology or prediction of mortality. Searches used Web of Science, PubMed and Science Direct. Search terms included “cognitive frailty” OR ((“cognitive decline” OR “cognitive impairment”) AND (frail*)), with terms to elicit mechanisms, predictors, causes, pathways and risk factors. To ensure inclusion of animal and cell models, keywords such as “behavioural” or “cognitive decline” or “senescence”, were added. 206 papers were included. Descriptive analysis provided high-level categorisation of determinants from social and environmental through psychological to biological. Patterns distinguishing CF from Alzheimer’s disease were identified and social and psychological moderators and mediators of underlying biological and physiological changes and of trajectories of CF development were suggested as foci for further research.